Alexander (Sasha) Sher

My research focuses on the retina and visual system. I use large scale multielectrode recording systems developed by physicists, biologists, and engineers to study the function, development, and treatment of neural circuits.

Sasha Sher: Research Interests

Our brain is a highly sophisticated system that receives information about the outside world, processes it, and determines our reaction to it. These functions are realized through billions of individual neurons that are connected in vast and complicated circuits and use electrical signals to communicate with each other. The Sher lab is using unique large scale multielectrode recording systems developed by a collaboration of physicists, biologists, and engineers to study function, development and treatment of neural circuits. Sher’s research is focused particularly on the retina and visual system. In addition, in collaboration with prof. Alan Litke, Sher lab participates in the development of new techniques for recording and stimulation of neural activity.

 

Publications

• • Beier C., Palanker D., Sher A., (2018)
    “Stereotyped Synaptic Connectivity Is Restored during Circuit Repair in the Adult Mammalian Retina,” Current Biology 28(11):1818-1824.e2.

• • Ho E.*, Smith R.*, Goetz G., Lei X., Galambos L., Kamins T.I., Harris J., Mathieson K., Palanker D. †, Sher A. †, (2018)
    “Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation,” Journal of Neurophysiology 119(2):389-400.

• • Pisano F.*, Zampaglione E.*, McAlinden N., Roebber J., Dawson M.D., Mathieson K. †, Sher A. †, (2017)
    “Large scale matching of function to the genetic identity of retinal ganglion cells,” Scientific Reports 7(1):15395.

• • Beier C., Hovhannisyan A., Weiser S., Kung J., Lee S., Lee D.Y., Huie P., Dalal R., Palanker D., Sher A., (2017)
    “Deafferented Adult Rod Bipolar Cells Create New Synapses with Photoreceptors to Restore Vision,” The Journal of Neuroscience 37(17):4635-4644.

• • Lorach H.*, Goetz G.*, Smith R., Lei X., Mandel Y., Kamins T., Mathieson K., Huie P., Harris J., Sher A. †, Palanker D. † (2015)
    “Photovoltaic restoration of sight with high visual acuity”. Nature Medicine. 21(5):476-82.

• • Sher A.*, Jones B.W., Huie P., Paulus Y.M., Lavinsky D., Leung L.S., Nomoto H., Beier C., Marc R.E., Palanker D.
    “Restoration of retinal structure and function after selective photocoagulation”, Journal of Neuroscience. 33(16):6800-8 (2013).

• • Sher A.*, DeVries S.H.
    “A non-canonical pathway for mammalian blue-green color vision”, Nature Neuroscience. 15(7): 952-3 (2012).

• • Mathieson K., Loudin J., Goetz G., Huie P., Wang L., Kamins T.I., Galambos L., Smith R., Harris J.S., Sher A.*, Palanker D.
    “Photovoltaic Retinal Prosthesis with High Pixel Density”, Nature Photonics. 6391-397 (2012).

• • Field GD, Gauthier JL, Sher A (first three are equal contributors), Greschner M, Machado TA, Jepson LH, Shlens J, Gunning DE, Mathieson K, Dabrowski W, Paninski L, Litke AM, Chichilnisky EJ.
    “Functional connectivity in the retina at the resolution of photoreceptors”, Nature. 467(7316):673-7 (2010).

• • Loudin JD, Cogan SF, Mathieson K, Sher A, and Palanker DV.
    “Photodiode Circuits for Retinal Prostheses”, IEEE Transactions on Biomedical Circuits and Systems. ahead-of-print access ISSN: 1932-4545 (2011).

• • Stafford BK, Sher A, Litke AM, Feldheim DA.
    “Spatial-temporal patterns of retinal waves underlying activity-dependent refinement of retinofugal projections”, Neuron. 64(2):200-12 (2009).

• • Elstrott J, Anishchenko A, Greschner M, Sher A, Litke AM, Chichilnisky EJ, Feller MB.
    “Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves”, Neuron. 58(4):499-506 (2008).

• • Field GD, Sher A, Gauthier J (first three are equal contributors), Greschner M, Shlens J, Litke AM, Chichilnisky EJ.
    “Spatial properties and functional organization of small bistratifed cells in primate retina”, Journal of Neuroscience, 27(48): 13261-13272 (2007).

• • Sher A., Chichilnisky E.J., Dabrowski W., Grillo A.A., Grivich M., Gunning D., Hottowy P., Kachiguine S., Litke A.M., Mathieson K. & Petrusca D.
    “Large-scale multielectrode recording and stimulation of neural activity”, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 579(2):895-900 (2007).

• • Litke A.M., Bezayiff N., Chichilnisky E.J., Cunningham W., Dabrowski W., Grillo A.A., Grivich M., Grybos P., Hottowy P., Kachiguine S., Kalmar R.S., Mathieson K., Petrusca D., Rahman M., & Sher A.
    “What does the eye tell the brain?: Development of a system for large-scale recording of retinal output activity”, IEEE Transactions on Nuclear Science 51(4): 1434-1440(2004).

• • Sher A., Appel R., Atoyan G.S., Bassalleck B., Bergman D.R., Cheung N., Dhawan S., Do H., Egger J., Eilerts S., Fischer H., Herold W., Issakov V.V., Kaspar H., Kraus D.E., Lazarus D.M., Lichard P., Lowe J., Lozano J., Ma H., Majid W., Pislak S., Poblaguev A.A., Rehak P., Sher Aleksey, Thompson J.A., Tru�l P.A., & Zeller M.E.
    “New, high statistics measurement of the K -> pi0 e+ nu branching ratio”, Physical Review Letters 91: 261802 (2003).

Neuroscience papers: https://pubmed.ncbi.nlm.nih.gov/?term=Sher+Alexander&sort=date
Publications directly related to neuroscience listed in PubMed 

My HEP papers: http://inspirebeta.net/search?p=author:A.Sher.%20and%20author:Thompson+

Publications related to my past work on rare kaon decays listed in inSPIRE 

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